General Cell Based Assays
Eurofins Discoverx PathHunter Mouse GALR1 β-Arrestin Cell-Based Assay Kit (CHO-K1)
The PathHunter Mouse GALR1 β-Arrestin Stable Cell Pool Assay (CHO-K1) contains a stable engineered cell pool used to measure mGALR1 (GPCR) activity via recruitment of β-Arrestin2. This is a complete kit that includes the cell pool vials, all required culture reagents for maintaining the cells in continuous culture, and detection reagents for running the assay.
Eurofins Discoverx PathHunter Human GPR83 β-Arrestin Cell-Based Assay Kit (CHO-K1)
The PathHunter Human GPR83 β-Arrestin Stable Cell Line Assay (CHO-K1) contains a stable clonal cell line used to measure GPR83 (GPCR) activity via recruitment of β-Arrestin2. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx PathHunter Human GPR143 β-Arrestin Cell-Based Assay Kit (CHO-K1)
The PathHunter Human GPR143 β-Arrestin Stable Cell Line Assay (CHO-K1) contains a stable clonal cell line used to measure GPR143 (GPCR) activity via recruitment of β-Arrestin2. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx PathHunter Human TACR3 β-Arrestin Cell-Based Assay Kit (CHO-K1)
The PathHunter Human TACR3 β-Arrestin Stable Cell Line Assay (CHO-K1) contains a stable clonal cell line used to measure TACR3 (GPCR) activity via recruitment of β-Arrestin2. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx PathHunter AGTRL1 Bioassay Kit, 2-Plate. (93-0250Y2-00121)
The PathHunter AGTRL1 Bioassay kit provides an easy-to-use cell based assay to measure drug potency and detect neutralizing antibodies. This bioassay assesses ligand (e.g. apelin-13) based activation of AGTRL1 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged AGTRL1 and EA-tagged β-Arrestin-2. Activation of AGTRL1 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. Bioassay kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, control agonist, detection reagent, and assay plates. For detailed product information, User manual and COA, visit www.discoverx.com/bioassay.
Eurofins Discoverx PathHunter eXpress EGFR/ErbB2 Dimerization Assay, 10pl Kit. (93-1051E3CP14L)
The PathHunter EGFR/ErbB2 Dimerization eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This kit assesses ligand (e.g. EGF) induced dimerization of EGFR/ErbB2 receptors. This product uses EFC technology. The cell line included overexpresses ErbB2 target protein fused to PK alongside EGFR target protein fused to EA. Upon ligand-induced dimerization of EGFR/ErbB2, detectable EFC signal is produced. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx cAMP Hunter eXpress VIPR2 CHO-K1 GPCR Assay, 2-Plate Kit. (95-0052E2CP2M)
The cAMP Hunter VIPR2 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. VIP) based activation of VIPR2 GPCR activity via detection of increasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type VIPR2, a naturally Gs coupled GPCR. Upon activation of VIPR2, the increase in levels of intracellular cAMP leads to an increased signal from EFC when the cAMP detection kit is applied. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter Human FFAR1 (GPR40) β-Arrestin Cell-Based Assay Kit (DLD1)
The PathHunter Human FFAR1 (GPR40) β-Arrestin Stable Cell Line Assay (DLD1) contains a stable clonal cell line used to measure FFAR1 (GPCR) activity via recruitment of β-Arrestin2. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx PathHunter Human BTLA Signaling Cell-Based Assay Kit (Jurkat)
The PathHunter Human BTLA (SHP1) Signaling Stable Cell Line Assay (Jurkat) measures BTLA signal by recruitment of SH2 domain protein to the activated receptor. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx PathHunter Human PTGIR Total GPCR Internalization Cell-Based Assay Kit (U2OS)
The PathHunter Human PTGIR Stable Cell Line Total GPCR Internalization Assay (U2OS) contains a stable clonal cell line used to measure PTGIR (GPCR) internalization via early-endosome localization. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
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